上級獣医学英語：専門語彙ガイド

"mast cell tumour grading"

The histopathological classification of canine mast cell tumours using the Patnaik or Kiupel two-tier grading system to predict biological behaviour and guide treatment decisions

"Mast cell tumour grading revealed a high-grade lesion by the Kiupel system, prompting referral for wide surgical excision with two-centimetre margins and adjuvant vinblastine-based chemotherapy."

"metronomic chemotherapy"

The continuous low-dose administration of cytotoxic drugs at intervals shorter than conventional cycles, primarily targeting tumour vasculature and regulatory T-cells rather than rapidly dividing tumour cells

"Metronomic chemotherapy with oral cyclophosphamide and piroxicam was initiated for the dog with transitional cell carcinoma of the bladder after surgical debulking was deemed unfeasible."

"stereotactic radiosurgery"

A precise radiation delivery technique that administers a high ablative dose to a well-defined tumour volume in one to five fractions using image guidance, sparing surrounding normal tissue

"Stereotactic radiosurgery using a linear accelerator was recommended for the intracranial meningioma in the geriatric Golden Retriever, offering a non-invasive alternative to craniotomy."

"tyrosine kinase inhibitor"

A targeted molecular therapy that blocks abnormal tyrosine kinase signalling in tumour cells, used in veterinary oncology primarily for mast cell tumours and gastrointestinal stromal tumours expressing mutant c-KIT

"Toceranib phosphate, a tyrosine kinase inhibitor, was prescribed after cytology confirmed c-KIT mutation in the recurrent mast cell tumour, resulting in a partial response lasting seven months."

"chemotherapy-induced myelosuppression"

The suppression of bone marrow haematopoiesis caused by cytotoxic drugs, leading to neutropenia, thrombocytopenia, and anaemia that require monitoring and dose adjustments

"Chemotherapy-induced myelosuppression was identified on a day-seven CBC showing a neutrophil count of 0.8 × 10⁹/L; the next doxorubicin dose was delayed by one week and reduced by 25%."

"lymphoma immunophenotyping"

The characterisation of lymphoma as B-cell or T-cell origin using flow cytometry or immunohistochemistry, which is critical for prognosis and treatment protocol selection

"Lymphoma immunophenotyping via flow cytometry on fine-needle aspirate confirmed a B-cell phenotype, guiding the oncologist to select the CHOP protocol with an expected median survival of 12 months."

"paraneoplastic syndrome"

A clinical disorder caused by tumour-secreted hormones, cytokines, or immune-mediated mechanisms rather than direct tumour invasion, commonly including hypercalcaemia, hypoglycaemia, or peripheral neuropathy

"Hypercalcaemia of 3.8 mmol/L without bony metastasis pointed to a paraneoplastic syndrome; a thorough work-up identified an anterior mediastinal mass consistent with T-cell lymphoma."

"palliative radiation therapy"

Radiation delivered with the intent of alleviating pain, reducing tumour burden, or improving quality of life rather than achieving cure, typically using fewer, larger fractions

"Palliative radiation therapy comprising four weekly fractions of 8 Gy was administered to the osteosarcoma-affected radius, providing significant pain relief and allowing the owner to delay amputation."

"fractional shortening"

An echocardiographic measurement of left ventricular systolic function calculated as the percentage reduction in left ventricular internal diameter between diastole and systole; normal range in dogs is 25–45%

"Fractional shortening had declined from 34% to 18% compared with the echocardiogram performed six months earlier, indicating progression to systolic dysfunction requiring introduction of pimobendan."

"occult dilated cardiomyopathy"

A preclinical phase of dilated cardiomyopathy in which ventricular dysfunction and arrhythmias are present but the dog remains asymptomatic, detectable only through echocardiography and Holter monitoring

"Screening of the Dobermann breeding colony identified occult dilated cardiomyopathy in three dogs; all showed ventricular premature complexes exceeding 100 per 24 hours on Holter monitoring despite normal clinical examinations."

"pulmonary hypertension grading"

The echocardiographic estimation of pulmonary arterial pressure using tricuspid regurgitation velocity, used to categorise disease severity and guide therapeutic decisions

"Pulmonary hypertension grading based on a tricuspid regurgitation velocity of 4.2 m/s indicated severe disease, and sildenafil was added to the existing furosemide and pimobendan regimen."

"ventricular premature complex"

An abnormal heartbeat originating in the ventricular myocardium before the next expected sinus impulse, appearing as a wide, aberrant QRS complex on electrocardiography without a preceding P-wave

"Ventricular premature complex burden on 24-hour Holter recording exceeded 300 per hour with R-on-T phenomenon observed, prompting initiation of mexiletine and a recheck in four weeks."

"pericardial effusion drainage"

The therapeutic or diagnostic removal of fluid from the pericardial sac via percutaneous pericardiocentesis, guided by echocardiography to relieve cardiac tamponade

"Pericardial effusion drainage under echocardiographic guidance yielded 480 mL of serosanguineous fluid; the dog's heart rate normalised from 180 to 110 bpm immediately following the procedure."

"patent ductus arteriosus occlusion"

The closure of a congenitally persistent ductus arteriosus connecting the aorta and pulmonary artery, achieved surgically via ligation or by minimally invasive transcatheter deployment of an Amplatz Canine Duct Occluder

"Patent ductus arteriosus occlusion using an Amplatz Canine Duct Occluder was performed via the femoral artery under fluoroscopic guidance, eliminating the left-to-right shunt with resolution of cardiomegaly at six-week recheck."

"atrioventricular block"

Impaired conduction from the atria to the ventricles through the atrioventricular node, classified as first-, second-, or third-degree depending on the severity and consistency of the conduction failure

"Third-degree atrioventricular block was confirmed on ECG by complete dissociation of P-waves and QRS complexes at a ventricular escape rate of 28 bpm; emergency transvenous pacing was placed pending permanent pacemaker implantation."

"N-terminal pro-B-type natriuretic peptide"

A cardiac biomarker released from ventricular myocytes in response to increased wall stress, used to detect occult cardiac disease, monitor heart failure progression, and guide treatment adjustments; abbreviated NT-proBNP

"An NT-proBNP concentration of 1800 pmol/L in a dyspnoeic Cavalier King Charles Spaniel strongly supported a cardiac rather than respiratory cause of respiratory distress, expediting echocardiographic examination."

"intervertebral disc herniation grading"

The classification of spinal cord compression severity from Hansen type I or II disc herniation using a five-grade neurological scale ranging from pain only (grade 1) to complete paralysis with absent deep pain (grade 5)

"Intervertebral disc herniation grading of 4 — paraplegia with intact deep pain — led the neurologist to recommend emergency decompressive surgery within 24 hours to maximise the probability of functional recovery."

"cerebrospinal fluid analysis"

Laboratory examination of CSF obtained by cisternal or lumbar puncture to identify inflammatory, infectious, neoplastic, or degenerative central nervous system disease through cell count, protein level, and cytology

"Cerebrospinal fluid analysis revealed a markedly elevated protein of 320 mg/dL with a mixed pleocytosis of 85 cells/µL, supporting a diagnosis of granulomatous meningoencephalitis rather than infectious encephalitis."

"status epilepticus management"

The emergency treatment of continuous or rapidly recurring seizure activity lasting more than five minutes, using a stepwise pharmacological protocol to terminate seizures and prevent permanent neurological damage

"Status epilepticus management was initiated with intravenous diazepam 0.5 mg/kg followed by a levetiracetam loading dose; the dog was transferred to ICU for continuous EEG monitoring and propofol infusion when seizures persisted."

"Wobbler syndrome"

A cervical spondylomyelopathy predominantly affecting large and giant breed dogs and horses, caused by dynamic or static compression of the cervical spinal cord, leading to progressive ataxia and tetraparesis

"MRI confirmed Wobbler syndrome with significant spinal cord compression at C5–C6 and C6–C7 in the Great Dane; a ventral slot decompression was performed at the most severely affected level."

"electroencephalography in veterinary patients"

The recording of brain electrical activity via scalp electrodes to characterise seizure type, identify epileptiform activity, and distinguish epilepsy from non-epileptic events in anaesthetised or sedated animals

"Electroencephalography in this veterinary patient performed under light propofol sedation revealed multifocal spike-wave complexes consistent with idiopathic epilepsy rather than a structural lesion."

"atlantoaxial instability"

Abnormal movement between the atlas and axis vertebrae due to malformation or absence of the dens, ligamentous laxity, or fracture, causing compression of the cervical spinal cord in small breed dogs

"Atlantoaxial instability in the Yorkshire Terrier was confirmed by dynamic radiography showing increased atlantoaxial angle in ventroflexion; surgical stabilisation with a ventral cross-pin and polymethylmethacrylate technique was performed."

"myasthenia gravis diagnosis"

The confirmation of autoimmune neuromuscular junction disease caused by acetylcholine receptor antibodies, characterised by episodic weakness exacerbated by exercise, diagnosed by serum antibody titre and pharmacological testing

"Myasthenia gravis diagnosis was established by a serum acetylcholine receptor antibody titre of 2.8 nmol/L; pyridostigmine was initiated and thoracic radiographs obtained to screen for concurrent thymoma."

"vestibular disease differentiation"

The clinical distinction between peripheral vestibular disease affecting the inner ear and central vestibular disease affecting the brainstem, based on the direction of nystagmus, head tilt, and presence of additional cranial nerve deficits

"Vestibular disease differentiation was guided by the presence of vertical nystagmus and ipsilateral facial nerve paresis, features consistent with central rather than peripheral vestibular disease, prompting urgent MRI."

"tibial plateau levelling osteotomy"

A surgical procedure for cranial cruciate ligament rupture in dogs that neutralises cranial tibial thrust by rotating the tibial plateau to achieve a 90-degree angle perpendicular to the patellar tendon; abbreviated TPLO

"Tibial plateau levelling osteotomy was performed on the left stifle after MRI confirmed complete cranial cruciate ligament rupture; the dog was bearing full weight by eight weeks post-operatively."

"laparoscopic ovariectomy"

A minimally invasive surgical technique for gonadectomy in female dogs and cats using a rigid endoscope and specialised instruments inserted through small port incisions in the abdominal wall

"Laparoscopic ovariectomy through two 5-mm ports was completed in 28 minutes; the owner reported significantly faster recovery compared with the dog's previous open splenectomy, with discharge the same evening."

"wound VAC therapy"

Negative-pressure wound therapy using a sealed foam dressing connected to a vacuum pump to remove exudate, reduce bacterial burden, promote granulation tissue formation, and prepare complex wounds for closure; abbreviated VAC

"Wound VAC therapy was applied to the degloving injury on the distal forelimb at -125 mmHg continuous pressure; granulation tissue covered the exposed bone by day seven, enabling delayed primary closure."

"total hip replacement"

The surgical replacement of the coxofemoral joint with a prosthetic implant system consisting of an acetabular cup and femoral stem, used to treat severe hip dysplasia, femoral head fractures, or refractory osteoarthritis in dogs

"Total hip replacement using a cementless BioMedtrix BFX system was performed on the five-year-old German Shepherd with end-stage hip dysplasia; limb function returned to near-normal within 12 weeks."

"pericardiectomy"

The surgical removal of a portion or the entire pericardial sac to prevent recurrence of cardiac tamponade, typically performed via thoracotomy or thoracoscopy in dogs with idiopathic or neoplastic pericardial effusion

"Subtotal pericardiectomy via right lateral thoracotomy was recommended after the dog presented with a third episode of cardiac tamponade; no effusion recurrence was detected at the six-month echocardiographic recheck."

"arthroscopic joint lavage"

A minimally invasive technique using an arthroscope inserted into a joint to visualise intra-articular pathology, remove inflammatory mediators and cartilage debris, and facilitate concurrent surgical interventions

"Arthroscopic joint lavage and removal of a fragmented medial coronoid process in the left elbow significantly reduced lameness scores and inflammatory markers in synovial fluid compared with pre-operative values."

"reconstructive flap surgery"

Surgical techniques that transfer vascularised local or regional tissue flaps — axial pattern, subdermal plexus, or free microvascular — to close skin defects that cannot be repaired by primary closure or simple tension-relief techniques

"Reconstructive flap surgery using a caudal superficial epigastric axial pattern flap was performed to close a large perianal defect following excision of a perianal adenocarcinoma, achieving primary healing by day 21."

"tracheal stenting"

The minimally invasive placement of a self-expanding metallic or silicone stent within the tracheal lumen under fluoroscopic guidance to relieve airway obstruction caused by tracheal collapse in toy breed dogs

"Tracheal stenting using a nitinol stent sized at 20% greater than the tracheal diameter was performed for refractory grade 4 tracheal collapse; the dog's cough frequency and exercise intolerance resolved within 48 hours."

"septic shock resuscitation"

The emergency treatment of life-threatening organ dysfunction caused by infection, prioritising intravenous fluid administration, early broad-spectrum antibiotics, vasopressor support, and source control

"Septic shock resuscitation was initiated with a 20 mL/kg isotonic crystalloid bolus and intravenous ampicillin-sulbactam pending blood culture results; norepinephrine was commenced when mean arterial pressure remained below 65 mmHg."

"mechanical ventilation in animals"

The use of a mechanical ventilator to support or replace spontaneous breathing in critically ill or anaesthetised animals, with parameters including tidal volume, respiratory rate, PEEP, and FiO₂ adjusted to individual patient requirements

"Mechanical ventilation in this animal was initiated for refractory hypoxaemia with a PaO₂/FiO₂ ratio of 80; lung-protective settings of 8 mL/kg tidal volume and PEEP of 6 cmH₂O were used to minimise ventilator-induced lung injury."

"disseminated intravascular coagulation"

A life-threatening coagulopathy in which widespread activation of coagulation pathways leads simultaneously to microvascular thrombosis and haemorrhage, consuming clotting factors and platelets; abbreviated DIC

"Disseminated intravascular coagulation was confirmed by prolonged PT and aPTT, thrombocytopenia of 42 × 10⁹/L, and elevated D-dimer; fresh frozen plasma and the underlying trigger — gastric dilatation-volvulus — were treated concurrently."

"oxygen cage therapy"

The delivery of an enriched oxygen environment to a dyspnoeic patient housed in a sealed enclosure maintaining FiO₂ between 40% and 60%, providing non-stressful oxygenation without the need for a facemask or nasal catheter

"Oxygen cage therapy at 50% FiO₂ was initiated for the feline asthmatic patient on admission; SpO₂ improved from 86% to 97% within ten minutes, allowing a calm examination without exacerbating bronchoconstriction."

"albumin transfusion"

The intravenous administration of canine-specific or human lyophilised albumin to correct severe hypoalbuminaemia, restore colloid oncotic pressure, and reduce oedema in critically ill patients

"Albumin transfusion with canine lyophilised albumin was administered over six hours to raise serum albumin from 10 to 18 g/L; peripheral oedema resolved over the following 48 hours as colloid oncotic pressure was restored."

"point-of-care ultrasound"

Rapid bedside ultrasound examination performed by the clinician managing the patient to answer focused clinical questions regarding fluid status, cardiac function, pneumothorax, and abdominal free fluid; abbreviated POCUS

"Point-of-care ultrasound using the TFAST protocol identified a pericardial effusion and pleural effusion within three minutes of the dog's arrival in respiratory distress, guiding immediate therapeutic drainage."

"vasopressor therapy"

The administration of catecholamine or non-catecholamine vasoactive drugs to restore systemic vascular resistance and mean arterial pressure in patients with distributive or vasodilatory shock unresponsive to fluid resuscitation

"Vasopressor therapy with norepinephrine at 0.1 mcg/kg/min was commenced via a central venous catheter after two crystalloid boluses failed to maintain mean arterial pressure above 65 mmHg in the dog with peritonitis."

"acute kidney injury staging"

The classification of acute renal dysfunction using the IRIS Acute Kidney Injury grading system based on creatinine elevation and urine output, used to guide fluid therapy, medication dose adjustments, and renal replacement therapy decisions

"Acute kidney injury staging at IRIS grade 3 was determined by a creatinine of 450 µmol/L rising from a baseline of 120 µmol/L; aggressive intravenous fluid diuresis was initiated and nephrotoxic drugs withdrawn."

"referral case workup"

The systematic diagnostic approach undertaken by a specialist when receiving a patient from a general practitioner, including review of prior records, targeted history-taking, and formulation of a prioritised differential diagnosis list

"Referral case workup at the internal medicine department revealed that the chronic coughing Labrador had previously been treated for infectious tracheobronchitis, but echocardiography confirmed occult dilated cardiomyopathy as the true cause."

"compassionate euthanasia discussion"

A structured end-of-life conversation with an owner that addresses prognosis, quality of life indicators, the euthanasia process, timing considerations, and available grief support services

"The compassionate euthanasia discussion focused on the dog's inability to rise unassisted and persistent pain despite maximum analgesia; the family appreciated receiving a written quality-of-life scale to help them with their decision."

"evidence-based medicine appraisal"

The critical evaluation of veterinary literature using systematic frameworks to assess study design, statistical validity, risk of bias, and clinical applicability before incorporating findings into practice

"Evidence-based medicine appraisal of the randomised controlled trial on tracheal stenting versus medical management concluded that the study had an unclear risk of bias and that results could not be directly extrapolated to toy breeds."

"continuing professional development"

The structured ongoing learning and skills maintenance activities that veterinary professionals undertake to remain current with scientific advances, maintain registration requirements, and improve clinical competence; abbreviated CPD

"Continuing professional development requirements under the RCVS Code of Professional Conduct mandate a minimum of 105 hours over three years, including evidence of reflection and its impact on clinical practice."

"One Health framework"

An interdisciplinary approach recognising the interconnection between human, animal, and environmental health, particularly relevant to zoonotic disease surveillance, antimicrobial resistance, and food safety

"The One Health framework guided the practice's antibiotic stewardship policy, aligning veterinary prescription patterns with national action plans on antimicrobial resistance to protect both animal patients and public health."

"board certification pathway"

The formal credentialling process through which a veterinarian achieves specialist recognition from a veterinary college such as the ACVIM, ECVIM, ACVS, or RCVS, requiring approved residency training, case logs, publications, and written and clinical examinations

"The intern began planning her board certification pathway in veterinary cardiology, identifying an ACVIM-approved residency programme and reviewing the case log requirements of 200 supervised cardiology cases over three years."

"triage scoring system"

A structured assessment tool such as the Animal Trauma Triage score or the Acute Patient Physiologic and Laboratory Evaluation score used to categorise patient severity on presentation and predict mortality risk

"A triage scoring system assessment on arrival assigned the hit-by-car Beagle an ATT score of 7 out of 18, indicating a poor prognosis; the owner was counselled accordingly before emergency exploratory laparotomy was undertaken."

"informed consent for advanced procedures"

The process of ensuring an owner understands the nature, risks, benefits, alternatives, and expected outcomes of a complex diagnostic or therapeutic intervention before providing written consent for the procedure

"Informed consent for the stereotactic radiosurgery procedure included a detailed explanation of the 3% risk of radiation necrosis, the three-visit treatment schedule, and the six-month MRI monitoring requirement; the owner signed after a second consultation."