Inglês para Farmácia: Vocabulário e Frases Essenciais

"sig code"

A shorthand Latin abbreviation on a prescription that instructs the patient how to take a medication

"The pharmacist decoded the sig code "ii tabs PO BID pc" as two tablets by mouth twice daily after meals."

"DAW"

Dispense As Written — a code indicating the prescriber requires the brand-name drug, not a generic substitute

"The physician wrote DAW on the script, meaning the pharmacy could not substitute a cheaper generic."

"refill authorisation"

Permission granted by the prescriber for the pharmacist to dispense additional supplies of a medication beyond the original quantity

"The patient requested a refill authorisation because her blood pressure tablets had run out."

"days supply"

The number of days a dispensed quantity of medication will last at the prescribed dosing frequency

"Insurance required a 30-day days supply, so 60 tablets at one tablet twice daily was the correct quantity."

"controlled substance"

A drug regulated under federal or national law due to its potential for abuse or dependence

"Dispensing the controlled substance required two pharmacist signatures and a DEA-compliant prescription."

"therapeutic substitution"

Replacing a prescribed drug with a different drug of the same pharmacological class deemed therapeutically equivalent

"With physician approval, the pharmacist performed a therapeutic substitution from one proton pump inhibitor to another."

"prior authorisation"

Approval that must be obtained from the insurance plan before a specific medication will be covered

"The specialty drug required prior authorisation, delaying treatment by three business days."

"unit dose"

A single pre-packaged amount of medication sufficient for one dose, used in hospital pharmacy systems

"The ward nurse retrieved a unit dose blister pack of metoprolol from the automated dispensing cabinet."

"mechanism of action"

The specific biochemical interaction through which a drug produces its therapeutic effect

"The mechanism of action of ACE inhibitors involves blocking the conversion of angiotensin I to angiotensin II."

"half-life"

The time required for the concentration of a drug in plasma to decrease by 50%

"Warfarin has a half-life of 36 to 42 hours, meaning dose adjustments take several days to reach steady state."

"first-pass effect"

The reduction in drug concentration that occurs as a medication passes through the liver before reaching systemic circulation

"Nitroglycerin undergoes a significant first-pass effect, which is why it is given sublingually rather than orally."

"bioavailability"

The proportion of a drug dose that reaches systemic circulation and is available to produce a therapeutic effect

"Oral morphine has about 30% bioavailability due to extensive first-pass metabolism in the liver."

"therapeutic index"

The ratio between the toxic dose and the therapeutic dose of a drug, used to indicate its safety margin

"Digoxin has a narrow therapeutic index, making regular plasma level monitoring essential for patient safety."

"receptor agonist"

A drug that binds to and activates a receptor, mimicking the effect of the body's natural ligand

"Salbutamol is a beta-2 receptor agonist that relaxes bronchial smooth muscle during an asthma attack."

"enzyme induction"

An increase in the activity of drug-metabolising enzymes caused by exposure to a drug or substance, leading to faster breakdown of other medications

"Rifampicin causes enzyme induction of CYP3A4, which significantly reduces plasma concentrations of oral contraceptives."

"loading dose"

A higher-than-maintenance initial dose used to rapidly achieve therapeutic drug concentrations

"An amiodarone loading dose was infused over 24 hours before switching to an oral maintenance regimen."

"medication adherence"

The degree to which a patient takes their medication as prescribed, including correct dose, timing, and duration

"Poor medication adherence in hypertensive patients is the most common reason for uncontrolled blood pressure."

"adverse drug reaction"

An unintended, harmful response to a medication taken at a normal therapeutic dose

"The patient reported a rash after starting amoxicillin; the pharmacist documented it as an adverse drug reaction."

"drug interaction"

A situation in which one drug alters the pharmacological effect of another drug when both are taken together

"The pharmacist warned the patient about a clinically significant drug interaction between warfarin and ibuprofen."

"contraindication"

A specific condition or factor that makes a particular treatment or medication inadvisable or unsafe to use

"Metformin has a contraindication in patients with severe renal impairment due to the risk of lactic acidosis."

"counselling point"

A key piece of information a pharmacist must communicate to a patient when dispensing a specific medication

"The top counselling point for methotrexate is to take it once weekly, never daily, to prevent toxicity."

"brown bag review"

A patient consultation in which all medications, including OTC products, are brought in and reviewed together for interactions and duplications

"During the brown bag review, the pharmacist discovered the patient was taking two different antihistamines simultaneously."

"pill burden"

The total number of tablets or capsules a patient must take daily, which can affect motivation and adherence

"The physician switched the patient to a combination tablet to reduce pill burden from six tablets to two."

"medication reconciliation"

The process of comparing a patient's current medication list with all medications ordered during care transitions to prevent errors

"On admission, the clinical pharmacist performed medication reconciliation to identify discrepancies before prescribing."

"pharmacokinetic monitoring"

The process of measuring drug levels in patient blood samples to optimise dosing and minimise toxicity

"Pharmacokinetic monitoring of vancomycin levels guided the team in adjusting the dose for adequate AUC targets."

"renal dose adjustment"

Modification of a drug's dose or frequency based on a patient's reduced kidney function to avoid toxic accumulation

"The pharmacist recommended a renal dose adjustment for gabapentin after calculating the patient's creatinine clearance."

"antimicrobial stewardship"

A coordinated program to optimise antibiotic use, improve patient outcomes, and reduce the emergence of resistant organisms

"As part of antimicrobial stewardship, the pharmacist recommended IV-to-oral switch once the patient's fever resolved."

"formulary management"

The process of selecting, reviewing, and maintaining the list of approved medications available within an institution

"The pharmacy and therapeutics committee evaluated a new anticoagulant for formulary management inclusion."

"deprescribing"

The planned and supervised process of reducing or stopping medications that are no longer indicated or may be causing harm

"The geriatric pharmacist initiated deprescribing of a proton pump inhibitor that the patient had taken unnecessarily for eight years."

"medication use evaluation"

A systematic review of drug use patterns within an institution to assess appropriateness, safety, and outcomes

"A medication use evaluation revealed that 40% of ceftriaxone prescriptions lacked documented indication in the chart."

"clinical decision support"

Automated alerts and tools within electronic health records that help clinicians make evidence-based prescribing decisions

"The clinical decision support alert fired when a physician entered a fluoroquinolone for a patient with a documented allergy."

"total parenteral nutrition"

Intravenous delivery of all nutritional requirements including glucose, amino acids, lipids, electrolytes, and vitamins for patients unable to tolerate enteral feeding

"The pharmacist designed a total parenteral nutrition formulation tailored to the patient's electrolyte levels and caloric needs."

"look-alike sound-alike"

Medications whose names or physical appearance are similar enough to cause confusion and dispensing errors

"Hydralazine and hydroxyzine are a classic look-alike sound-alike pair that has caused serious dispensing errors."

"high-alert medication"

A drug that bears a heightened risk of causing significant patient harm when used in error

"Concentrated potassium chloride is a high-alert medication that must be stored separately from all other injectables."

"black box warning"

The FDA's most serious warning label, appearing in a bordered box, indicating a drug carries a significant risk of serious adverse effects

"The black box warning on fluoroquinolones alerts prescribers to the risk of tendon rupture and peripheral neuropathy."

"post-market surveillance"

Ongoing monitoring of a drug's safety and effectiveness after it has been approved and released to the public

"Post-market surveillance identified a rare but serious cardiac event not detected in pre-approval clinical trials."

"recall"

A request from the manufacturer or health authority to return or remove a drug product from the market due to safety or quality concerns

"A nitrosamine contamination prompted the recall of thousands of lots of the antihypertensive valsartan worldwide."

"root cause analysis"

A systematic investigation method used after a medication error to identify underlying causes and prevent recurrence

"The root cause analysis of the insulin overdose revealed the issue was caused by a labelling ambiguity in the pharmacy system."

"pharmacovigilance"

The science and activities relating to the detection, assessment, understanding, and prevention of adverse effects of medicines

"National pharmacovigilance programmes collect spontaneous reports from healthcare professionals and patients to detect safety signals."

"expiry date"

The date after which a manufacturer guarantees the potency, safety, and quality of a medication

"The technician checked every shelf during the weekly audit and pulled medications past their expiry date for disposal."

"beyond-use date"

The date after which a compounded preparation must not be used, assigned based on stability data rather than manufacturing date

"The compounded oral suspension was assigned a beyond-use date of 14 days when stored under refrigeration."

"aseptic technique"

A set of practices and procedures performed to minimise contamination by microorganisms during preparation of sterile products

"Strict aseptic technique was followed during preparation of the TPN bag in the laminar airflow workbench."

"cleanroom"

A controlled environment with a specified particle count and air quality standard used for sterile pharmaceutical compounding

"Staff were required to don full gowning before entering the ISO Class 7 cleanroom for sterile compounding."

"GMP"

Good Manufacturing Practice — a system of regulations ensuring pharmaceutical products are consistently produced and controlled to quality standards

"An FDA inspection cited the facility for multiple GMP violations including inadequate environmental monitoring."

"excipient"

Any inactive ingredient in a pharmaceutical formulation that aids delivery, stability, or palatability of the active drug

"The patient's documented allergy to a particular excipient required the pharmacist to source an alternative formulation."

"osmolarity"

The concentration of solutes in a solution, used to ensure intravenous preparations are compatible with blood

"The peripheral IV solution was formulated below 900 mOsm/L to avoid osmolarity-related phlebitis."

"stability testing"

Studies conducted on a drug formulation to determine how long it retains potency, safety, and quality under specified storage conditions

"Stability testing showed the reconstituted antibiotic suspension retained full potency for 10 days at room temperature."

"laminar airflow workbench"

A benchtop device that provides an ISO Class 5 particle-free work environment for preparing sterile injectable medications

"All chemotherapy agents were prepared inside the laminar airflow workbench to protect both the product and the technician."